Many of us know that cannabis is full of beneficial compounds, but most medical marijuana doctors pay attention only to the effects of such cannabinoids as THC and CBD. However, recent studies have revealed that cannabidivarin, or CBDV, has a great potential for treating epilepsy and other neurological diseases. What is CBDV and how it can help medical marijuana users?
Cannabidivarin (CBDV) is a homolog of cannabidiol (CBD) that is also free of any psychoactive effects. Unlike CBD, this cannabinoid includes a propyl chain instead of a pentane ring, which provides it with additional properties.
The effects of CBDV are similar to those of CBD, so this cannabinoid can also be used for treating various medical conditions. Scientists have discovered that CBDV is very effective for relieving epileptic seizures and reducing convulsions.
CBDV is a rare cannabinoid that can be found in landrace and feral indica with a low content of THC and a high level of CBD. Some marijuana strains cultivated in northwestern India, Mexico, and Pakistan have a high concentration of CBDV.
Scientists suppose that CBDV appears from the reaction between cannabigerolic acid and CBD synthase. This assumption has not been studied properly yet, but it is definitely known that THCV is formed when cannabigerovarin acid (CBGVA) interacts with THCV synthase.
The following marijuana strains are high in CBD, so they are more likely to include CBDV:
A 2013 study on rats discovered that cannabis extracts with a high content of CBDV had anticonvulsant properties. The findings allowed scientists to conclude that CBDV was potentially effective for treating epilepsy.
Moreover, in 2014 ACS Chemical Neuroscience published a study conducted by Italian researchers where both CBD and CBDV showed multiple effects in reducing and modulating epileptic seizures.
After analyzing the therapeutic effects of this cannabinoid, GW Pharmaceuticals and Otsuka Pharmaceuticals patented a whole-plant extract rich in CBDV and CBD. This medicine was specially developed for treating neurological disorders accompanied by hyper-excitability of the central nervous system that resulted in epileptic seizures and convulsions.
In addition, CBDV has an effect similar to CBD, which has beneficial properties for treating Parkinson's disease.
Besides, CBDV has proven to be effective in reducing the vomiting and nausea caused by various drugs and medical conditions. In 2013, the British Journal of Pharmacology published a study where both THCV and CBDV showed positive results in reducing nausea and vomiting in patients with Crohn's disease and cancer.